STIC is fading away but ovarian serous carcinoma continues

Several years ago, the fallopian tube was proposed as the origin of ovarian serous carcinoma. We were also told that we had not notice this because we were reviewing only one section, usually from the middle portion of the fallopian tube. A new SEE-FIM protocol was started and everybody submitted the entire fallopian tube. This is the data from one of the groups that proposed the origin of ovarian cancer from the fallopian tube:

In 2000 !n 2008 In 2016

STIC in High grade serous Ca Most cases, but they were 40% 21%

missed because the SEE-FIM

protocol was not used

However, there was the possibility that STIC was deeper in the block, therefore the authors selected 32 cases of high grade serous carcinoma that were negative for STIC. They serially sectioned all blocks ( at 2 blocks per case, that would be around 9.600 sections). Four new cases were found ( 12%). Therefore, if we serially section the entire fallopian tube, and look at the 300 slides, we will identify 33% STIC in high grade serous carcinoma.

Is anyone going to be brave and write a paper saying that most high grade serous are not associated with STIC?

Abstracts 1180 and 1234