Rejected Papers

Rejected Papers

1-Spontaneous vs Induced abortions. I have been working at Cedars-Sinai Hospital in LA where abortions could be spontaneous or induced. I also work at Baylor Hospital in Dallas where only spontaneous abortions are seen. I have noticed that the placental cell islands are different in both types. Spontaneous abortions have more placental cell islands which contain more fibrinoid material. I do not know if these changes are the cause or the effect of the type of abortion, but they should be investigated.

2-Ovarian follicular cysts in the medulla. In cases of multiple follicular cysts frequently some cysts are found in the medulla of the ovary. This is a very unusual location because primordial follicles are seen in the cortex of the ovary. Reviewing numerous cases of normal ovaries I found that in some cases, in the medulla of the ovary, nodules of spindle cells, similar to the cells in the cortex. This is not unusual in perimenopausal women, probably a reaction to the FSH stimulation, in these cases primordial follicles are not seen in these nodules. However, in some cases primordial follicles are found in these nodules in the medulla. I believe these cases represent a abnormal development of the ovary, and these primordial follicles could be the origin of follicular cysts in the medulla.

3-In cases of ovarian serous cystadenofibromas, low grade serous neoplasms can be seen in the peritoneum. We presented an abstract with Dr Carmen Tornos many years ago. This can be seen in 5% of peri, or postmenopausal women. There was a very long discussion regarding the terminology of the peritoneal lesions, but no discussion about the concept.

Terminology is very important but ignoring the idea, the concept that could be crucial to understand multicentricity in ovarian cancer is difficult to understand.

I hope some future studies would try to confirm, or deny, these rejected concepts. I believe they are important to improve the care of women.