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No fallopian tube, no problem, still primary. Really?

  • elviogsilva
  • Apr 25, 2017
  • 1 min read

A group of prestigious Gyn pathologists published in 2015 (Modern Path 28,1101-1122) guidelines for assigning the site of origin of extrauterine high-grade serous carcinomas. I disagree with the idea that STIC represents the primary origin for the majority of ovarian serous carcinoma, but I understand why many people would be persuaded to consider a STIC as a primary lesion. However, categorizing the fallopian tube as the primary site when there is no STIC, but tumor in the wall of the tube, and even when the fallopian tube is not found but there is tumor in the adnexal area is going too far. The adnexal area also has peritoneal surface and also includes the ovary. Assigning the fallopian tube as the primary site in these cases negates the possibility of the tumor arising in these other areas of Mullerian epithelium.

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